Ex-soldier Frank Brayker is the guardian of an ancient key that can unlock tremendous evil; the sinister Collector is a demon who wants the key so he can initiate the apocalypse. On the run from wicked mercenaries for almost 90 years, Brayker finally stops in at a boarding house in New Mexico where -- with the help of its residents -- he plans to face off against the Collector and his band of ghouls, preventing them from ever seizing the key.
After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.